A hypotheses for elucidating novel COVID-19 disease
Elevated of hydrogen peroxide causes suppressed innate immunity and lung injuries in antioxidant enzyme deficient COVID-19 patients
Abstract: We propose a top-down approach for elucidating novel COVID-19 disease which caused unprecedented social and economic devastations globally. Detrimental outcome of antioxidant enzyme deficiency and synergism between SARS-CoV-2 virus and a bacterial pathogen, Streptococcus pneumoniae is the most likely cause of COVID-19-associated mortalities. As we age, production of the antioxidant catalase enzyme, which catalyzes the decomposition of hydrogen peroxide (H2O2) to water and oxygen, tails off; as a result, H2O2 starts to accumulate in body. Additional production of H2O2 by the bacteria increases H2O2 concentration up to a critical level in respiratory tract. The elevated H2O2 causes damages in lungs and oxidizes key components of the innate immune system, halts inflammasome activation process, and eventually suppresses it.
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Nanostructured surfaces combined with active carbon fiber filter for collection of hydrogen peroxide residues.
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trio (/ˈtriːəʊ/): a group of three chemical agents used to destroy microorganisms and viruses
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